Comparative analysis of metazoan chromatin organization

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Comparative analysis of metazoan chromatin organization

Genome function is regulated dynamically in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in C. elegans and D. melanogaster have contributed significantly to our understanding of molecular mechanisms of genome function in humans, and revealed conservation of chromatin components and mechanisms1–3. Nevertheless, the three orga...

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Chromatin Organization

Although the Victorian proverb ‘‘everything in its place and a place for everything’’ is meant for orderly households, it could just as easily describe the organization of eukaryotic genomes. This issue’s Select profiles articles that reveal new insights into how DNA is packaged and partitioned into three-dimensional (3D) structures throughout the life of a cell, shedding new light on how inter...

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ژورنال

عنوان ژورنال: Nature

سال: 2014

ISSN: 0028-0836,1476-4687

DOI: 10.1038/nature13415